Origin of aromatase inhibitory activity via proteochemometric modeling
نویسندگان
چکیده
منابع مشابه
Origin of aromatase inhibitory activity via proteochemometric modeling
Aromatase, the rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer. Side effects due to aromatase inhibitors (AIs) necessitate the pursuit of novel inhibitor candidates with high selectivity, lower toxicity and increased potency. Designing a novel therapeutic agent against aromatase could be a...
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ژورنال
عنوان ژورنال: PeerJ
سال: 2016
ISSN: 2167-8359
DOI: 10.7717/peerj.1979